{"id":14252,"date":"2019-01-24T07:41:01","date_gmt":"2019-01-24T07:41:01","guid":{"rendered":"https:\/\/clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/"},"modified":"2019-09-19T07:38:51","modified_gmt":"2019-09-19T07:38:51","slug":"cientificos-espanoles-retrasar-artrosis","status":"publish","type":"post","link":"https:\/\/www.clinicacemtro.com\/en\/cientificos-espanoles-retrasar-artrosis\/","title":{"rendered":"Cient\u00edficos espa\u00f1oles desarrollan un sistema de modulaci\u00f3n epigen\u00e9tica para retrasar la artrosis"},"content":{"rendered":"

Cient\u00edficos espa\u00f1oles del Instituto Salk de California y la Cl\u00ednica CEMTRO de Madrid, liderados por el Prof. Juan Carlos Izpis\u00faa, han aplicado un sistema de modulaci\u00f3n epigen\u00e9tica para aumentar la expresi\u00f3n de la prote\u00edna DNA Metil-transferasa 3b en las c\u00e9lulas del cart\u00edlago, que conducir\u00eda a frenar el desarrollo de la artrosis<\/strong>.<\/p>\n

La artrosis es una enfermedad cr\u00f3nica que ocurre cuando falta el cart\u00edlago articular, lo que provoca que los huesos rocen y aparezca el dolor. Seg\u00fan la Organizaci\u00f3n Mundial de la Salud<\/a>, cerca del 28% de la poblaci\u00f3n mundial mayor de 60 a\u00f1os presenta artrosis y el 80% de \u00e9sta tiene limitaciones en sus movimientos<\/strong>.<\/p>\n

El proyecto, que ha recibido una menci\u00f3n especial en el 6th ICRS Summit celebrado en San Diego, California (USA) y en el que participan Cl\u00ednica CEMTRO<\/a>, la Fundaci\u00f3n Dr. Pedro Guill\u00e9n y la Fundaci\u00f3n Mapfre<\/strong>, busca encontrar un m\u00e9todo para retrasar el desarrollo de artrosis<\/strong> en seres humanos mediante modulaci\u00f3n epigen\u00e9tica del genoma.<\/p>\n

\"Retrasar<\/p>\n

A medida que envejecemos no cambia la cantidad de genes que contiene nuestro ADN, pero s\u00ed la forma en la que la informaci\u00f3n gen\u00e9tica se expresa. La epigen\u00e9tica hace referencia a ese proceso de regulaci\u00f3n de la expresi\u00f3n de los genes que cambia en el envejecimiento<\/strong>.<\/p>\n

Un estudio reciente publicado en la revista JCI Insight<\/a> indica que, en el cart\u00edlago articular los niveles de la enzima epigen\u00e9tica Dnmt3b disminuyen en los condrocitos (c\u00e9lulas del cart\u00edlago) durante el proceso de artrosi<\/strong>s. De hecho, ratones sanos a los que se les bloquea la producci\u00f3n de esta prote\u00edna desarrollan artrosis mucho antes que aquellos en los que los niveles de Dnmt3b son normales.<\/p>\n

En este estudio los cient\u00edficos han provocado un da\u00f1o qu\u00edmico en las articulaciones de los ratones que se ha demostrado que disminuye los niveles de la prote\u00edna Dnmt3b y que produce artrosis. En estos animales se ensayar\u00e1 si la modulaci\u00f3n epigen\u00e9tica de la prote\u00edna Dnm3tb conduce a un enlentecimiento en la progresi\u00f3n de esta enfermedad<\/strong>.<\/p>\n

\"Investigacion<\/p>\n

Los resultados de esta investigaci\u00f3n arrojan esperanza en la b\u00fasqueda de terapias eficaces para una enfermedad que supone la principal causa de discapacidad y dolor en el mundo<\/strong>. Los siguientes pasos de la investigaci\u00f3n estar\u00e1n encaminados a conseguir de una forma sencilla la aplicaci\u00f3n de esta terapia para posteriormente comenzar los ensayos en humanos.<\/p>\n

Esta terapia permitir\u00eda aumentar o recuperar los niveles de la enzima durante el proceso de envejecimiento y los primeros estadios del desarrollo de artrosis para prevenir el agravamiento de esta enfermedad. Por lo tanto, se trata de una terapia preventiva que permita revertir o retrasar el inicio de la artrosis<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cient\u00edficos espa\u00f1oles del Instituto Salk de California y la Cl\u00ednica CEMTRO de Madrid, liderados por el Prof. Juan Carlos Izpis\u00faa, han aplicado un sistema de modulaci\u00f3n epigen\u00e9tica para aumentar la expresi\u00f3n de la prote\u00edna DNA Metil-transferasa 3b en las c\u00e9lulas del cart\u00edlago, que conducir\u00eda a frenar el desarrollo de la artrosis. La artrosis es una…<\/p>\n","protected":false},"author":2,"featured_media":13736,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[558],"tags":[590],"class_list":["post-14252","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-en","tag-artrosis-en"],"acf":[],"yoast_head":"\nUn paso m\u00e1s cerca de curar la artrosis - Cl\u00ednica CEMTRO<\/title>\n<meta name=\"description\" content=\"Cient\u00edficos espa\u00f1oles han aplicado un sistema de modulaci\u00f3n epigen\u00e9tica que conducir\u00eda a Frenar Desarrollo de Artrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un paso m\u00e1s cerca de curar la artrosis - Cl\u00ednica CEMTRO\" \/>\n<meta property=\"og:description\" content=\"Cient\u00edficos espa\u00f1oles han aplicado un sistema de modulaci\u00f3n epigen\u00e9tica que conducir\u00eda a Frenar Desarrollo de Artrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Cl\u00ednica CEMTRO\" \/>\n<meta property=\"article:published_time\" content=\"2019-01-24T07:41:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-09-19T07:38:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.clinicacemtro.com\/wp-content\/uploads\/2019\/01\/Medicos_Cemtro_Frenar_Artrosis.png\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Comunicaci\u00f3n Cemtro\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Comunicaci\u00f3n Cemtro\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/\"},\"author\":{\"name\":\"Comunicaci\u00f3n Cemtro\",\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/en\\\/#\\\/schema\\\/person\\\/c5c00f21986e4bc9f0ad75977dce6042\"},\"headline\":\"Cient\u00edficos espa\u00f1oles desarrollan un sistema de modulaci\u00f3n epigen\u00e9tica para retrasar la artrosis\",\"datePublished\":\"2019-01-24T07:41:01+00:00\",\"dateModified\":\"2019-09-19T07:38:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/\"},\"wordCount\":494,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.clinicacemtro.com\\\/wp-content\\\/uploads\\\/2019\\\/01\\\/Medicos_Cemtro_Frenar_Artrosis.png\",\"keywords\":[\"artrosis\"],\"articleSection\":[\"Noticias\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/\",\"url\":\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/\",\"name\":\"Un paso m\u00e1s cerca de curar la artrosis - Cl\u00ednica CEMTRO\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.clinicacemtro.com\\\/wp-content\\\/uploads\\\/2019\\\/01\\\/Medicos_Cemtro_Frenar_Artrosis.png\",\"datePublished\":\"2019-01-24T07:41:01+00:00\",\"dateModified\":\"2019-09-19T07:38:51+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/en\\\/#\\\/schema\\\/person\\\/c5c00f21986e4bc9f0ad75977dce6042\"},\"description\":\"Cient\u00edficos espa\u00f1oles han aplicado un sistema de modulaci\u00f3n epigen\u00e9tica que conducir\u00eda a Frenar Desarrollo de Artrosis.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/cientificos-espanoles-retrasar-artrosis\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.clinicacemtro.com\\\/wp-content\\\/uploads\\\/2019\\\/01\\\/Medicos_Cemtro_Frenar_Artrosis.png\",\"contentUrl\":\"https:\\\/\\\/www.clinicacemtro.com\\\/wp-content\\\/uploads\\\/2019\\\/01\\\/Medicos_Cemtro_Frenar_Artrosis.png\",\"width\":600,\"height\":400,\"caption\":\"Medicos Cemtro Frenar Artrosis\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.clinicacemtro.com\\\/en\\\/\",\"name\":\"Cl\u00ednica CEMTRO\",\"description\":\"\",\"alternateName\":\"Cl\u00ednica CEMTRO\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.clinicacemtro.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.clinicacemtro.com\\\/en\\\/#\\\/schema\\\/person\\\/c5c00f21986e4bc9f0ad75977dce6042\",\"name\":\"Comunicaci\u00f3n Cemtro\",\"url\":\"https:\\\/\\\/www.clinicacemtro.com\\\/en\\\/author\\\/comucemtro\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Un paso m\u00e1s cerca de curar la artrosis - Cl\u00ednica CEMTRO","description":"Cient\u00edficos espa\u00f1oles han aplicado un sistema de modulaci\u00f3n epigen\u00e9tica que conducir\u00eda a Frenar Desarrollo de Artrosis.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/","og_locale":"en_US","og_type":"article","og_title":"Un paso m\u00e1s cerca de curar la artrosis - Cl\u00ednica CEMTRO","og_description":"Cient\u00edficos espa\u00f1oles han aplicado un sistema de modulaci\u00f3n epigen\u00e9tica que conducir\u00eda a Frenar Desarrollo de Artrosis.","og_url":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/","og_site_name":"Cl\u00ednica CEMTRO","article_published_time":"2019-01-24T07:41:01+00:00","article_modified_time":"2019-09-19T07:38:51+00:00","og_image":[{"width":600,"height":400,"url":"https:\/\/www.clinicacemtro.com\/wp-content\/uploads\/2019\/01\/Medicos_Cemtro_Frenar_Artrosis.png","type":"image\/png"}],"author":"Comunicaci\u00f3n Cemtro","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Comunicaci\u00f3n Cemtro","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/#article","isPartOf":{"@id":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/"},"author":{"name":"Comunicaci\u00f3n Cemtro","@id":"https:\/\/www.clinicacemtro.com\/en\/#\/schema\/person\/c5c00f21986e4bc9f0ad75977dce6042"},"headline":"Cient\u00edficos espa\u00f1oles desarrollan un sistema de modulaci\u00f3n epigen\u00e9tica para retrasar la artrosis","datePublished":"2019-01-24T07:41:01+00:00","dateModified":"2019-09-19T07:38:51+00:00","mainEntityOfPage":{"@id":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/"},"wordCount":494,"commentCount":0,"image":{"@id":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/#primaryimage"},"thumbnailUrl":"https:\/\/www.clinicacemtro.com\/wp-content\/uploads\/2019\/01\/Medicos_Cemtro_Frenar_Artrosis.png","keywords":["artrosis"],"articleSection":["Noticias"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/","url":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/","name":"Un paso m\u00e1s cerca de curar la artrosis - Cl\u00ednica CEMTRO","isPartOf":{"@id":"https:\/\/www.clinicacemtro.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/#primaryimage"},"image":{"@id":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/#primaryimage"},"thumbnailUrl":"https:\/\/www.clinicacemtro.com\/wp-content\/uploads\/2019\/01\/Medicos_Cemtro_Frenar_Artrosis.png","datePublished":"2019-01-24T07:41:01+00:00","dateModified":"2019-09-19T07:38:51+00:00","author":{"@id":"https:\/\/www.clinicacemtro.com\/en\/#\/schema\/person\/c5c00f21986e4bc9f0ad75977dce6042"},"description":"Cient\u00edficos espa\u00f1oles han aplicado un sistema de modulaci\u00f3n epigen\u00e9tica que conducir\u00eda a Frenar Desarrollo de Artrosis.","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.clinicacemtro.com\/cientificos-espanoles-retrasar-artrosis\/#primaryimage","url":"https:\/\/www.clinicacemtro.com\/wp-content\/uploads\/2019\/01\/Medicos_Cemtro_Frenar_Artrosis.png","contentUrl":"https:\/\/www.clinicacemtro.com\/wp-content\/uploads\/2019\/01\/Medicos_Cemtro_Frenar_Artrosis.png","width":600,"height":400,"caption":"Medicos Cemtro Frenar Artrosis"},{"@type":"WebSite","@id":"https:\/\/www.clinicacemtro.com\/en\/#website","url":"https:\/\/www.clinicacemtro.com\/en\/","name":"Cl\u00ednica CEMTRO","description":"","alternateName":"Cl\u00ednica CEMTRO","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.clinicacemtro.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.clinicacemtro.com\/en\/#\/schema\/person\/c5c00f21986e4bc9f0ad75977dce6042","name":"Comunicaci\u00f3n Cemtro","url":"https:\/\/www.clinicacemtro.com\/en\/author\/comucemtro\/"}]}},"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/posts\/14252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/comments?post=14252"}],"version-history":[{"count":0,"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/posts\/14252\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/media\/13736"}],"wp:attachment":[{"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/media?parent=14252"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/categories?post=14252"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.clinicacemtro.com\/en\/wp-json\/wp\/v2\/tags?post=14252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}